ObjectiveTo investigate the effect of NMDA receptor antagonist MK801 on the negative affection induced by withdrawal from acute morphine dependence in rats.

目的谷氨酸NMDA受体拮抗剂地卓西平（MK801）对大鼠急性吗啡依赖戒断性情绪反应的影响。

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Nitric oxide, an intracellular messenger molecule linked to activation of N Methyl D aspartate(NMDA) receptor, plays a role in morphine tolerance and dependence.

一氧化氮（NO）是与N 甲基D 天（门）冬氨酸（NM DA）受体活性相关的一种细胞内信使分子，在吗啡耐受和依赖中起作用。

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OBJECTIVE:To elucidate the effect of ondansetron(OND), a 5-HT3 receptor antagonist, on the morphine-induced conditioned place preference(CPP) in mice and its possible mechanism.

目的：探讨5-HT3型受体特异性拮抗剂奥丹西隆对吗啡诱导的条件性位置偏爱（CPP）效应的影响及其可能机制。

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